The innate immune sensor STING and STING controlled cytosolic DNA innate immune signaling pathway was discovered by the laboratory of Glen N Barber (Nature, 2008).  STING senses cyclic dinucleotides (CDN’s) generated by intracellular bacteria or produced by cytosolic DNA species via a cellular CDN synthase, cGAS. STING agonists are potent activators of cytokine production which are essential for generating anti-microbial and anti-tumor immune responses. Stimulation of the STING pathway has been shown to exert potent anti-tumor immune responses and may have significant potential in anti-microbial treatments and as adjuvants for novel vaccine development.